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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR001046",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0046873",
"name": "metal ion transmembrane transporter activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0030001",
"name": "metal ion transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"hamap": {
"MF_00221": "Divalent metal cation transporter MntH [mntH]"
},
"pfam": {
"PF01566": "Natural resistance-associated macrophage protein-like"
},
"ncbifam": {
"TIGR01197": "metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family"
},
"panther": {
"PTHR11706": "SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"
},
"prints": {
"PR00447": "NATRESASSCMP"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001046",
"name": "NRAMP family",
"type": "Family",
"children": [
{
"accession": "IPR017187",
"name": "Ethylene-insensitive protein 2",
"type": "Family",
"children": []
}
]
},
"name": {
"name": "NRAMP family",
"short": "NRAMP_fam"
},
"description": [
{
"text": "<p>The natural resistance-associated macrophage protein (NRAMP) family consists of animal NRAMP1, NRAMP2 (DMT1), yeast proteins Smf1 and Smf2 and bacterial homologues such as divalent metal cation transporters (MntH) [[cite:PUB00005530], [cite:PUB00004854], [cite:PUB00003001], [cite:PUB00101161], [cite:PUB00101162], [cite:PUB00101160], [cite:PUB00101163]]. The NRAMP family includes functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. These membrane proteins are divalent cation transporters which have a high degree of sequence conservation, particularly, the residues contributing to ion interaction are strongly conserved (DPGN and MPH motifs) [[cite:PUB00101161], [cite:PUB00101162]].</p>\n\n<p>NRAMP1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis, where it plays an essential role in host defense against pathogens. Mutations in NRAMP1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis [[cite:PUB00002034]]. NRAMP2 (DMT1) is a multiple divalent cation transporter broadly expressed in the duodenum, kidney, brain, testis and placenta. It transports Fe2+, Mn2+ and Cd+2, whereas Zn2+ is a poor substrate. Ca+2 and Mg+2 are not transported, which is important because their high concentrations in duodenum, where NRAMP2 is expressed at high levels, would interfere with the absorption of Fe2+ [[cite:PUB00101161]]. It is the major transferrin-independent iron uptake system in mammals [[cite:PUB00002034], [cite:PUB00101161]].</p>\n\n<p>NRAMP related members of this family have substrate specificity for Mn2+ and/or Mg2+, such as the yeast proteins Smf1 and Smf2 [[cite:PUB00003001]] and a group of bacterial transporters (NrmT, for Nramp-related magnesium transporter) [[cite:PUB00101163]]. This entry also includes related metal transporters such as nitrite/nitrate transporters.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00004854": {
"PMID": 7479731,
"ISBN": null,
"volume": "92",
"issue": "22",
"year": 1995,
"title": "Nramp defines a family of membrane proteins.",
"URL": null,
"raw_pages": "10089-93",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Cellier M",
"Prive G",
"Belouchi A",
"Kwan T",
"Rodrigues V",
"Chia W",
"Gros P."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7479731&action=stream&blobtype=pdf"
},
"PUB00002034": {
"PMID": 9719491,
"ISBN": null,
"volume": "47",
"issue": "7",
"year": 1998,
"title": "Macrophage NRAMP1 and its role in resistance to microbial infections.",
"URL": null,
"raw_pages": "277-84",
"medline_journal": "Inflamm Res",
"ISO_journal": "Inflamm. Res.",
"authors": [
"Govoni G",
"Gros P."
],
"DOI_URL": "http://dx.doi.org/10.1007/s000110050330"
},
"PUB00101162": {
"PMID": 28059071,
"ISBN": null,
"volume": "8",
"issue": null,
"year": 2017,
"title": "Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family.",
"URL": null,
"raw_pages": "14033",
"medline_journal": "Nat Commun",
"ISO_journal": "Nat Commun",
"authors": [
"Ehrnstorfer IA",
"Manatschal C",
"Arnold FM",
"Laederach J",
"Dutzler R."
],
"DOI_URL": null
},
"PUB00101161": {
"PMID": 30714568,
"ISBN": null,
"volume": "8",
"issue": null,
"year": 2019,
"title": "Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter. ",
"URL": null,
"raw_pages": "e41124",
"medline_journal": "Elife",
"ISO_journal": "Elife",
"authors": [
"Bozzi AT",
"Zimanyi CM",
"Nicoludis JM",
"Lee BK",
"Zhang CH",
"Gaudet R."
],
"DOI_URL": null
},
"PUB00101160": {
"PMID": 25326704,
"ISBN": null,
"volume": "21",
"issue": "11",
"year": 2014,
"title": "Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.",
"URL": null,
"raw_pages": "990-6",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat Struct Mol Biol",
"authors": [
"Ehrnstorfer IA",
"Geertsma ER",
"Pardon E",
"Steyaert J",
"Dutzler R."
],
"DOI_URL": null
},
"PUB00003001": {
"PMID": 9360964,
"ISBN": null,
"volume": "272",
"issue": "46",
"year": 1997,
"title": "Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family.",
"URL": null,
"raw_pages": "28933-8",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Pinner E",
"Gruenheid S",
"Raymond M",
"Gros P."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.272.46.28933"
},
"PUB00005530": {
"PMID": 8928221,
"ISBN": null,
"volume": "12",
"issue": "6",
"year": 1996,
"title": "Resistance to intracellular infections: comparative genomic analysis of Nramp.",
"URL": null,
"raw_pages": "201-4",
"medline_journal": "Trends Genet",
"ISO_journal": "Trends Genet.",
"authors": [
"Cellier M",
"Belouchi A",
"Gros P."
],
"DOI_URL": "http://dx.doi.org/10.1016/0168-9525(96)30042-5"
},
"PUB00101163": {
"PMID": 24968120,
"ISBN": null,
"volume": "10",
"issue": "6",
"year": 2014,
"title": "Transport of magnesium by a bacterial Nramp-related gene.",
"URL": null,
"raw_pages": "e1004429",
"medline_journal": "PLoS Genet",
"ISO_journal": "PLoS Genet",
"authors": [
"Shin JH",
"Wakeman CA",
"Goodson JR",
"Rodionov DA",
"Freedman BG",
"Senger RS",
"Winkler WC."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 205,
"interactions": 0,
"matches": 42010,
"pathways": 40,
"proteins": 41325,
"proteomes": 14178,
"sets": 0,
"structural_models": {
"alphafold": 32670,
"bfvd": 0
},
"structures": 30,
"taxa": 26873
},
"entry_annotations": {
"alignment:seed": 69,
"alignment:full": 18016
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
