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InterPro-Version: 108.0
InterPro-Version-Minor: 0
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{
"metadata": {
"accession": "IPR000802",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0015105",
"name": "arsenite transmembrane transporter activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0015700",
"name": "arsenite transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd01118": "ArsB_permease"
},
"prints": {
"PR00758": "ARSENICPUMP"
},
"ncbifam": {
"TIGR00935": "arsenite/antimonite efflux transporter"
},
"pfam": {
"PF02040": "Arsenical pump membrane protein"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR000802",
"name": "Arsenical pump membrane protein, ArsB",
"type": "Family",
"children": []
},
"name": {
"name": "Arsenical pump membrane protein, ArsB",
"short": "Arsenical_pump_ArsB"
},
"description": [
{
"text": "<p>Arsenic is a toxic metalloid whose trivalent and pentavalent ions inhibit a variety of biochemical processes. Operons that encode arsenic resistance have been found in multicopy plasmids from both Gram-positive and Gram-negative bacteria [[cite:PUB00002267]]. The resistance mechanism is encoded from a single operon, which houses an anion pump. The pump has two polypeptide components: a catalytic subunit (the ArsA protein), which functions as an oxyanion-stimulated ATPase; and an arsenite export component (the ArsB protein), which is associated with the inner membrane [[cite:PUB00002587]]. The ArsA and ArsB proteins are thought to form a membrane complex that functions as an anion-translocating ATPase.</p>\n\n<p>The ArsB protein is distinguished by its overall hydrophobic character, in keeping with its role as a membrane-associated channel. Sequence analysis reveals the presence of 13 putative transmembrane (TM) regions.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00002267": {
"PMID": 7721697,
"ISBN": null,
"volume": "177",
"issue": "8",
"year": 1995,
"title": "An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteria.",
"URL": null,
"raw_pages": "2050-6",
"medline_journal": "J Bacteriol",
"ISO_journal": "J. Bacteriol.",
"authors": [
"Diorio C",
"Cai J",
"Marmor J",
"Shinder R",
"DuBow MS."
],
"DOI_URL": "http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7721697&action=stream&blobtype=pdf"
},
"PUB00002587": {
"PMID": 1688427,
"ISBN": null,
"volume": "265",
"issue": "1",
"year": 1990,
"title": "Molecular characterization of an anion pump. The ArsB protein is the membrane anchor for the ArsA protein.",
"URL": null,
"raw_pages": "190-4",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Tisa LS",
"Rosen BP."
],
"DOI_URL": "http://intl.jbc.org/cgi/reprint/265/1/190.pdf"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 18,
"interactions": 0,
"matches": 40821,
"pathways": 0,
"proteins": 16075,
"proteomes": 7397,
"sets": 0,
"structural_models": {
"alphafold": 12082,
"bfvd": 0
},
"structures": 0,
"taxa": 13502
},
"entry_annotations": {
"alignment:seed": 1,
"alignment:full": 1713
},
"cross_references": {
"gp": {
"displayName": "Genome Properties",
"description": "Genome properties is an annotation system whereby functional attributes can be assigned to a genome, based on the presence of a defined set of protein signatures within that genome.",
"rank": 45,
"accessions": [
{
"accession": "GenProp0474",
"url": "https://www.ebi.ac.uk/interpro/genomeproperties/genome-property/GenProp0474"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
