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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR000330",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF00176": "SNF2-related domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR014001",
"name": "Helicase superfamily 1/2, ATP-binding domain",
"type": "Domain",
"children": [
{
"accession": "IPR000330",
"name": "SNF2, N-terminal domain",
"type": "Domain",
"children": [
{
"accession": "IPR028727",
"name": "Chromodomain-helicase-DNA-binding protein 5, DEAH-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR031047",
"name": "DNA helicase INO80, DEAQ-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044753",
"name": "HELLS, N-terminal",
"type": "Domain",
"children": []
},
{
"accession": "IPR044754",
"name": "Isw1/2, N-terminal",
"type": "Domain",
"children": []
},
{
"accession": "IPR044755",
"name": "SMARCA1, N-terminal",
"type": "Domain",
"children": []
},
{
"accession": "IPR057342",
"name": "RapA, DEXH-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR058052",
"name": "ERCC6L2-like, DEXH-box helicase domain",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR006935",
"name": "Helicase/UvrB, N-terminal",
"type": "Domain",
"children": [
{
"accession": "IPR044749",
"name": "FANCM, DEAH-box helicase domain",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR011492",
"name": "Non-structural protein NS3-like, DEAD-box helicase, flavivirus",
"type": "Domain",
"children": []
},
{
"accession": "IPR011545",
"name": "DEAD/DEAH-box helicase domain",
"type": "Domain",
"children": [
{
"accession": "IPR033517",
"name": "DDX54/DBP10 family, DEAD-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044113",
"name": "DDX41, DEAD-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044447",
"name": "DHX9, DEXH-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044728",
"name": "ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044742",
"name": "RhlB-like, DEAD/DEAH-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044756",
"name": "DHX15, DEXH-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044763",
"name": "Ded1/Dbp1, DEAD-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044764",
"name": "DDX52/Rok1, DEAD-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044765",
"name": "DDX47/Rrp3, DEAD-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044773",
"name": "DDX18/Has1, DEAD-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR049614",
"name": "HrpB, DEXH-box helicase domain",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR030100",
"name": "SWI/SNF complex subunit BRG1, ATP-binding",
"type": "Domain",
"children": []
},
{
"accession": "IPR040980",
"name": "SWI2/SNF2 ATPase",
"type": "Domain",
"children": []
},
{
"accession": "IPR044078",
"name": "Mot1, ATP-binding domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044573",
"name": "ARIP4, DEXH-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044762",
"name": "DHX8/ Prp22, DEXH-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044774",
"name": "Suv3, DEXQ-box helicase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR060542",
"name": "Probable helicase domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "SNF2, N-terminal domain",
"short": "SNF2_N"
},
"description": [
{
"text": "<p>This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54) and chromatin unwinding (e.g., ISWI), as well as several other proteins with limited functional information (e.g., lodestar, ETL1) [[cite:PUB00014473], [cite:PUB00014474], [cite:PUB00095659]]. SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in increased accessibility of DNA to transcription factors [[cite:PUB00096999]]. Proteins containing this domain appear to be distantly related to the DEAD/DEAH box helicases.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00014473": {
"PMID": 7651832,
"ISBN": null,
"volume": "23",
"issue": "14",
"year": 1995,
"title": "Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions.",
"URL": null,
"raw_pages": "2715-23",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Eisen JA",
"Sweder KS",
"Hanawalt PC."
],
"DOI_URL": "http://dx.doi.org/10.1093/nar/23.14.2715"
},
"PUB00014474": {
"PMID": 14729263,
"ISBN": null,
"volume": "326",
"issue": null,
"year": 2004,
"title": "The SNF2 domain protein family in higher vertebrates displays dynamic expression patterns in Xenopus laevis embryos.",
"URL": null,
"raw_pages": "59-66",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Linder B",
"Cabot RA",
"Schwickert T",
"Rupp RA."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.gene.2003.09.053"
},
"PUB00096999": {
"PMID": 16935875,
"ISBN": null,
"volume": "34",
"issue": "15",
"year": 2006,
"title": "Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures.",
"URL": null,
"raw_pages": "4160-7",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Durr H",
"Flaus A",
"Owen-Hughes T",
"Hopfner KP."
],
"DOI_URL": null
},
"PUB00095659": {
"PMID": 21549307,
"ISBN": null,
"volume": "42",
"issue": "3",
"year": 2011,
"title": "Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.",
"URL": null,
"raw_pages": "285-96",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol Cell",
"authors": [
"Rowbotham SP",
"Barki L",
"Neves-Costa A",
"Santos F",
"Dean W",
"Hawkes N",
"Choudhary P",
"Will WR",
"Webster J",
"Oxley D",
"Green CM",
"Varga-Weisz P",
"Mermoud JE."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR027417",
"name": "P-loop containing nucleoside triphosphate hydrolase",
"type": "homologous_superfamily"
},
{
"accession": "IPR038718",
"name": "SNF2-like, N-terminal domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 3192,
"interactions": 0,
"matches": 192160,
"pathways": 171,
"proteins": 187873,
"proteomes": 17140,
"sets": 0,
"structural_models": {
"alphafold": 102076,
"bfvd": 74
},
"structures": 202,
"taxa": 36102
},
"entry_annotations": {
"alignment:seed": 18,
"alignment:full": 112616
},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "3.6.4.-",
"url": "https://enzyme.expasy.org/EC/3.6.4.-"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
