Gene summary: sequence, alignment information, cellular phenotypes observed

Gene summary: PTPRC

Gene information:

Synonyms:: CD45, GP180, LCA, T200

Gene description:: protein tyrosine phosphatase, receptor type, C [Source:HGNC Symbol;Acc:HGNC:9666]

Ensembl ID:: ENSG00000081237

Protein domains: (provided by InterPro)

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Gene Ontology:

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Gene Ontology:

ENST00000367379,
ENST00000442510,
ENST00000348564,
ENST00000367367,
ENST00000530727:

peptidyl-tyrosine dephosphorylation

ENST00000442510,
ENST00000348564:

dephosphorylation; phosphatase activity

ENST00000367379,
ENST00000442510,
ENST00000348564,
ENST00000529828,
ENST00000367367,
ENST00000530727:

T cell receptor signaling pathway; protein tyrosine phosphatase activity

ENST00000442510,
ENST00000348564,
ENST00000529828,
ENST00000367367,
ENST00000530727:

protein binding; protein dephosphorylation

ENST00000442510:

B cell differentiation; B cell proliferation; B cell receptor signaling pathway; T cell differentiation; T cell proliferation; activation of MAPK activity; axon guidance; bone marrow development; cell cycle phase transition; cell periphery; cell surface; cell surface receptor signaling pathway; defense response to virus; external side of plasma membrane; extracellular vesicular exosome; focal adhesion; hematopoietic progenitor cell differentiation; heparan sulfate proteoglycan binding; heparin binding; heterotypic cell-cell adhesion; immunoglobulin biosynthetic process; integral component of membrane; integral component of plasma membrane; leukocyte cell-cell adhesion; membrane; membrane raft; negative regulation of T cell mediated cytotoxicity; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cytokine-mediated signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein autophosphorylation; negative regulation of protein kinase activity; negative thymic T cell selection; plasma membrane; positive regulation of B cell proliferation; positive regulation of MAPK cascade; positive regulation of T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive regulation of alpha-beta T cell proliferation; positive regulation of antigen receptor-mediated signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of gamma-delta T cell differentiation; positive regulation of hematopoietic stem cell migration; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of isotype switching to IgG isotypes; positive regulation of protein kinase activity; positive regulation of stem cell proliferation; positive thymic T cell selection; protein kinase binding; regulation of B cell differentiation; regulation of B cell receptor signaling pathway; regulation of cell cycle; regulation of extrinsic apoptotic signaling pathway; regulation of humoral immune response mediated by circulating immunoglobulin; release of sequestered calcium ion into cytosol; response to gamma radiation; stem cell development; transmembrane receptor protein tyrosine phosphatase activity

Phenotypes observed:

Observed phenotypes (?): These terms represent the phenotypic classes observed following the suppression of the expression of the selected gene across independent screens	Assigned ontology terms (?): These terms represent the cellular phenotype ontology terms assigned to the observed phenotypes	Screen (?) Screen ID link to additional information available for each study and screen	Reagent ID (?) Each identifier represents a reagent that was used in a particular screen to suppress the expression of its target gene and for which a phenotype has been observed. The reagents listed here uniquely map to their target gene. The reagent ID displayed is the SysMicro internal ID
			AMBN10007137	AMBN10007138	AMBN10049396	QIAGN0054556	QIAGN0054829	QIAGN0054949
Intracellular retention of SH4(HASPB)-GFP	Decreased rate of intracellular protein transport	B1_SyM_1	0.5	0.5
Intracellular retention of SH4(YES)-mCherry	Decreased rate of intracellular protein transport	B1_SyM_1			0.5
Normal mitotic exit	Exit from mitosis	P1_SyM_1				1	1	1
All genes with the same set of phenotypes (number of genes / number of reagents):		phenotype view ontology view	2814 / 3029 Phenotype set for these genes/reagents: — Intracellular retention of SH4(HASPB)-GFP 2814 / 3029 Ontology set for these genes/reagents: — Decreased rate of intracellular protein transport	2814 / 3029 Phenotype set for these genes/reagents: — Intracellular retention of SH4(HASPB)-GFP 2814 / 3029 Ontology set for these genes/reagents: — Decreased rate of intracellular protein transport	984 / 1013 Phenotype set for these genes/reagents: — Intracellular retention of SH4(YES)-mCherry 984 / 1013 Ontology set for these genes/reagents: — Decreased rate of intracellular protein transport	219 / 583 Phenotype set for these genes/reagents: — Normal mitotic exit 219 / 583 Ontology set for these genes/reagents: — Exit from mitosis	219 / 583 Phenotype set for these genes/reagents: — Normal mitotic exit 219 / 583 Ontology set for these genes/reagents: — Exit from mitosis	219 / 583 Phenotype set for these genes/reagents: — Normal mitotic exit 219 / 583 Ontology set for these genes/reagents: — Exit from mitosis

1 .. 0.5

— evidence (reproducibility)

Reagents with no phenotype:

Reagents, targeting this gene, but with no phenotype revealed (or revealed with low evidence) for the following screens:

Reagent	Screen ID	Study Title	Screen type
AMBN10007136	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary
AMBN10007136	M1_SyM_1	Mitocheck	Primary
AMBN10007137	M1_SyM_1	Mitocheck	Primary
AMBN10007138	M1_SyM_1	Mitocheck	Primary
AMBN10049385	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary
AMBN10049385	M1_SyM_1	Mitocheck	Primary
AMBN10049396	M1_SyM_1	Mitocheck	Primary
AMBN20056977	B1_SyM_2	BZH_SH4-mCherry-GFP	Validation
AMBN20056978	B1_SyM_2	BZH_SH4-mCherry-GFP	Validation
DHARM0008931	P2_SyM_1	Phagokinetic track	Primary

Cellular Phenotype Database

Gene summary: PTPRC