Gene summary: sequence, alignment information, cellular phenotypes observed

Gene summary: GCLM

Gene information:

Gene description:: glutamate-cysteine ligase, modifier subunit [Source:HGNC Symbol;Acc:HGNC:4312]

Protein domains: (provided by InterPro)

show

Gene Ontology:

show

Phenotypes observed:

Observed phenotypes (?): These terms represent the phenotypic classes observed following the suppression of the expression of the selected gene across independent screens	Assigned ontology terms (?): These terms represent the cellular phenotype ontology terms assigned to the observed phenotypes	Screen (?) Screen ID link to additional information available for each study and screen	Reagent ID (?) Each identifier represents a reagent that was used in a particular screen to suppress the expression of its target gene and for which a phenotype has been observed. The reagents listed here uniquely map to their target gene. The reagent ID displayed is the SysMicro internal ID
			AMBN10009808
Intracellular retention of SH4(HASPB)-GFP	Decreased rate of intracellular protein transport	B1_SyM_1	0.5
Intracellular retention of SH4(YES)-mCherry	Decreased rate of intracellular protein transport	B1_SyM_1	0.5
All genes with the same set of phenotypes (number of genes / number of reagents):		phenotype view ontology view	930 / 947 Phenotype set for these genes/reagents: — Intracellular retention of SH4(HASPB)-GFP — Intracellular retention of SH4(YES)-mCherry 930 / 947 Ontology set for these genes/reagents: — Decreased rate of intracellular protein transport — Decreased rate of intracellular protein transport

1 .. 0.5

— evidence (reproducibility)

Not unique targeting:

List of reagents also targeting this gene, but not uniquely (?)

Screen ID	Study Title	Screen type	Reagent
B1_SyM_1	BZH_SH4-mCherry-GFP	Primary	AMBN10046721

Reagents with no phenotype:

Reagents, targeting this gene, but with no phenotype revealed (or revealed with low evidence) for the following screens: