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CHEBI:7514 - neostigmine
| Formula | C12H19N2O2 |
| Net Charge | +1 |
| Average Mass | 223.296 |
| Monoisotopic Mass | 223.14410 |
| SMILES | CN(C)C(=O)Oc1cccc([N+](C)(C)C)c1 |
| InChI | InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1 |
| InChIKey | ALWKGYPQUAPLQC-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | EC 3.1.1.7 (acetylcholinesterase) inhibitor An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid. anti-obesity agent Any substance which is used to reduce or control weight. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. gastrointestinal drug A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion. renoprotective agent Any compound that is able to prevent damage to the kidneys. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antidote to curare poisoning A role borne by a molecule that acts to counteract or neutralize the deleterious effects of curare. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| neostigmine (CHEBI:7514) has role analgesic (CHEBI:35480) |
| neostigmine (CHEBI:7514) has role anti-obesity agent (CHEBI:74518) |
| neostigmine (CHEBI:7514) has role antidote to curare poisoning (CHEBI:74530) |
| neostigmine (CHEBI:7514) has role antiglaucoma drug (CHEBI:39456) |
| neostigmine (CHEBI:7514) has role antineoplastic agent (CHEBI:35610) |
| neostigmine (CHEBI:7514) has role EC 3.1.1.7 (acetylcholinesterase) inhibitor (CHEBI:38462) |
| neostigmine (CHEBI:7514) has role gastrointestinal drug (CHEBI:55324) |
| neostigmine (CHEBI:7514) has role renoprotective agent (CHEBI:231911) |
| neostigmine (CHEBI:7514) is a quaternary ammonium ion (CHEBI:35267) |
| Incoming Relation(s) |
| neostigmine bromide (CHEBI:179557) has part neostigmine (CHEBI:7514) |
| IUPAC Name |
|---|
| 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium |
| Synonyms | Source |
|---|---|
| 3-Trimethylammoniumphenyl N,N-dimethylcarbamate | ChemIDplus |
| Eustigmin | ChemIDplus |
| Eustigmine | ChemIDplus |
| (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate | ChemIDplus |
| Miostin | ChEMBL |
| m-Trimethylammoniumphenyldimethylcarbamate | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| 1897 | DrugCentral |
| C07258 | KEGG COMPOUND |
| D08261 | KEGG DRUG |
| DB01400 | DrugBank |
| HMDB0015472 | HMDB |
| LSM-5360 | LINCS |
| Neostigmine | Wikipedia |
| Citations |
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