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CHEBI:8364 - prazosin
| Formula | C19H21N5O4 |
| Net Charge | 0 |
| Average Mass | 383.408 |
| Monoisotopic Mass | 383.15935 |
| SMILES | COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC |
| InChI | InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) |
| InChIKey | IENZQIKPVFGBNW-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). |
| Applications: | antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| prazosin (CHEBI:8364) has role antihypertensive agent (CHEBI:35674) |
| prazosin (CHEBI:8364) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) |
| prazosin (CHEBI:8364) has role α-adrenergic antagonist (CHEBI:37890) |
| prazosin (CHEBI:8364) is a aromatic ether (CHEBI:35618) |
| prazosin (CHEBI:8364) is a furans (CHEBI:24129) |
| prazosin (CHEBI:8364) is a monocarboxylic acid amide (CHEBI:29347) |
| prazosin (CHEBI:8364) is a piperazines (CHEBI:26144) |
| prazosin (CHEBI:8364) is a quinazolines (CHEBI:38530) |
| Incoming Relation(s) |
| prazosin hydrochloride (CHEBI:8365) has part prazosin (CHEBI:8364) |
| IUPAC Name |
|---|
| 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine |
| INNs | Source |
|---|---|
| prazosin | WHO MedNet |
| prazosina | WHO MedNet |
| prazosine | WHO MedNet |
| prazosinum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine | ChemIDplus |
| 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline | ChemIDplus |
| Citations |
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