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CHEBI:68845 - azilsartan medoxomil

Default Structure
ChEBI IDCHEBI:68845
ChEBI Nameazilsartan medoxomil
Stars
DefinitionA carboxylic ester obtained by formal condensation of the carboxy group of azilsartan with the hydroxy group of 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one. A prodrug for azilsartan, it is used for treatment of hypertension.
Last Modified22 February 2017
SubmitterSteve
DownloadsMolfile
FormulaC30H24N4O8
Net Charge0
Average Mass568.542
Monoisotopic Mass568.15941
SMILESCCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)n2)cc1
InChIInChI=1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)
InChIKeyQJFSABGVXDWMIW-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
angiotensin receptor antagonist  A hormone antagonist that blocks angiotensin receptors.
Applications:
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
angiotensin receptor antagonist  A hormone antagonist that blocks angiotensin receptors.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
azilsartan medoxomil (CHEBI:68845) has functional parent azilsartan (CHEBI:68850)
azilsartan medoxomil (CHEBI:68845) has role angiotensin receptor antagonist (CHEBI:61016)
azilsartan medoxomil (CHEBI:68845) has role antihypertensive agent (CHEBI:35674)
azilsartan medoxomil (CHEBI:68845) has role prodrug (CHEBI:50266)
azilsartan medoxomil (CHEBI:68845) is a 1,2,4-oxadiazole (CHEBI:46809)
azilsartan medoxomil (CHEBI:68845) is a aromatic ether (CHEBI:35618)
azilsartan medoxomil (CHEBI:68845) is a benzimidazoles (CHEBI:22715)
azilsartan medoxomil (CHEBI:68845) is a carboxylic ester (CHEBI:33308)
azilsartan medoxomil (CHEBI:68845) is a cyclic carbonate ester (CHEBI:46838)
azilsartan medoxomil (CHEBI:68845) is a dioxolane (CHEBI:39430)
azilsartan medoxomil (CHEBI:68845) is conjugate acid of azilsartan medoxomil(1−) (CHEBI:68849)
Incoming Relation(s)
azilsartan medoxomil(1−) (CHEBI:68849) is conjugate base of azilsartan medoxomil (CHEBI:68845)
IUPAC Name 
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1-benzimidazole-7-carboxylate
INNs  Source
azilsartan medoxomilWHO MedNet
azilsartan médoxomilWHO MedNet
azilsartán medoxomiloWHO MedNet
azilsartanum medoxomilumWHO MedNet
Brand Name  Source
EdarbiChEBI
Manual XrefsDatabases
4322DrugCentral
AzilsartanWikipedia
D08067KEGG DRUG
US2005187269Patent
Registry NumbersSources
Reaxys:12326818Reaxys
CAS:863031-21-4KEGG DRUG
CAS:863031-21-4ChemIDplus
Citations