E-MTAB-794 - Transcriptional profiling by array in rat of age-dependent gene expression in sensorimotor cortex following spinal cord injury
Released on 15 January 2012, last updated on 2 May 2014
In this study, we investigated the extent and nature of the difference between the dynamic cortical gene expression profiles of aged (22-month-old) and young (2-month-old) rats following thoracic corticospinal tract (CST) transection and whether the anti-scarring-treatment (AST)-induced regeneration program can be activated in aged animals. GeneChip analysis was performed on layers V/VI of the rat sensorimotor cortex at 1, 7 and 35 days post operation (dpo), which represented the acute, subacute and chronic stages of SCI, respectively. Anti-scarring treatment (AST) includes local injections of an iron chelator and cAMP immediately after SCI. For our purpose we used the Affymetrix GeneChip Rat Gene 1.0 ST Array (A-AFFY-160) which contains approximately 27,000 genes.
transcription profiling by array, compound treatment, development or differentiation, injury, time series
Age-dependent modulation of cortical transcriptomes in spinal cord injury and repair. Jaerve A, Kruse F, Malik K, Hartung HP, Müller HW. :e49812 (2012), PMID:23236355
Shaping age-specific cortical transcriptomes during spinal cord injury repair. Anne Jaerve; Fabian Kruse; Katharina Malik; Hans-Peter Hartung; Hans Werner Mueller.