E-MTAB-7928 - Baseline expression of symptomatic and asymptomatic subjects after YF17D vaccination in Trial 1

Status
Submitted on 2 January 2016, last updated on 11 May 2019, released on 11 May 2019
Organism
Homo sapiens
Samples (27)
Array (1)
Protocols (7)
Description
This study investigates how the baseline expression level of genes impact symptomatic outcome of flaviviral infection. Before given the YF17D vaccine, whole blood was extracted into tempus tubes from vaccinated subjects. Thereafter, the subjects were assessed if they experienced adverse events (or symptoms). 27 subjects (n=19 symptomatic, n=8 asymptomatic) were processed according to manufacturer's protocol. Transcript expression was then evaluated by Affymetrix Human GeneChip 2.0 ST array, performed at Duke-NUS Genome Biology Core Facility. Data analysis and processing was performed using Partek software and enriched pathways determined by Reactome database from Enrichr.
Experiment types
transcription profiling by array, disease state design
Contact
Citation
Metabolic perturbations and cellular stress underpin susceptibility to symptomatic yellow fever infection. Kuan Rong Chan, Esther Shuyi Gan, Candice Yuen Yue Chan, Cui Liang, John Zhong Heng Low, Summer Li-Xin Zhang1, Eugenia Ziying Ong, Ashwin Bhatta, Limin Wijaya, Yie Hou Lee, Jenny Guek-Hong Low, Eng Eong Ooi.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-7928.idf.txt
Sample and data relationshipE-MTAB-7928.sdrf.txt
Raw data (1)E-MTAB-7928.raw.1.zip
Processed data (1)E-MTAB-7928.processed.1.zip
Array designA-GEOD-16686.adf.txt
Links