E-MTAB-7678 - scRNA-seq analysis of lung CD64-expressing mononuclear cells, patrolling and classical monocytes from steady-state C57BL/6J mice
Last updated on 23 July 2019, released on 31 July 2019
We sought to evaluate in an unbiased way the heterogeneity of lung interstitial macrophages and their relationship with alveolar macrophages, lung Ly-6Chi classical monocytes and Ly-6Clo patrolling monocytes, by single cell RNA-Seq.
RNA-seq of coding RNA from single cells, observational design
Two distinct populations of monocyte-derived long-lived interstitial macrophages and NR4A1-dependent local precursors populate the lung interstitial CD64+ compartment. Joey Schyns, Qiang Bai, Cécilia Ruscitti, Coraline Radermecker, Sebastiaan De Schepper, Svetoslav Chakarov, Dimitri Pirottin, Florent Ginhoux, Guy Boeckxstaens, Fabrice Bureau, Thomas Marichal.