E-MTAB-6885 - miRseq Analysis of Human Macrophages Co-cultured with MCF-7 Breast Cancer Cells
Submitted on 20 April 2015, last updated on 8 February 2019, released on 8 February 2019
Tumor-immune cell interactions shape the immune cell phenotype, with microRNAs (miRs) being crucial components of this crosstalk. How they are transferred, and how they affect their target landscape, especially in tumor-associated macrophages (TAMs), is largely unknown. Here we aimed to define miRome of TAMs and identify novel miRs those are deferentially expression in TAMs and decipher their functional relevance in disease settings.
microRNA profiling by high throughput sequencing, cell type comparison design, stimulus or stress design
Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype. Ann-Christin Frank, Stefanie Ebersberger, Sebastian Lampe, Andreas Weigert, Tobias Schmid, Ingo Ebersberger, Shahzad Nawaz Syed and Bernhard Brüne.