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E-MTAB-6337 - ATAC-seq on ESCs undergoing directed differentiation towards defined neural fates
Status | Last updated on 27 August 2018, released on 27 August 2018 | ||||||||||
Organism | Mus musculus | ||||||||||
Samples (44) | |||||||||||
Protocols (6) | |||||||||||
Description | We have used ATAC-seq to track cell state changes that occur during the differentiation of mouse embryonic stem cells to defined neural progenitor fates. We have performed ATAC-seq every 24 hours in cells en route to 3 distinct neural progenitors fates, anterior, hindbrain and spinal cord. This has allowed us to define how cells transition to a neural state, based on their enhancer usage. We identified regions distinct to different anterior-posterior neural progenitors, and validated their relevance by performing in vivo ATAC-seq on neural progenitors isolated from different axial levels of mouse embryos. | ||||||||||
Experiment type | ATAC-seq | ||||||||||
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Citation | Regionalization of the nervous system requires axial allocation prior to neural lineage commitment. Vicki Metzis, Sebastian Steinhauser, Edvinas Pakanavicius, Mina Gouti, Despina Stamataki, Robin Lovell-Badge, Nicholas M Luscombe and James Briscoe. | ||||||||||
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