E-MTAB-5817 - ChIP-Seq mapping of histone modifications at multiple DNA Double Strand Breaks
Submitted on 5 June 2017, last updated on 20 August 2018, released on 27 September 2018
DNA Double Strands Breaks (DSBs) are highly detrimental since they can lead to mutations and chromosomes rearrangements (amplification, deletion, translocation and chromosome loss). Here, we used in a standardized system, where multiples DSBs are induced at defined positions across the human genome (U2OS-DIvA cells), to describe the distribution of eighteen histone modifications before and after damage using ChIP-Seq. This provides a comprehensive picture of the chromatin landscape induced at DSBs.
ChIP-seq, compound treatment design
A Biernacka, B Fongfang, Clouaire Thomas, François Aymard, Gaëlle LEGUBE <firstname.lastname@example.org>, Jason Iacovoni, K Ginalski, M Rowicka, M Skrzypczak, Marion Aguirrebengoa <email@example.com>, N Dojer, Vincent ROCHER <firstname.lastname@example.org>