E-MTAB-5686 - Determination of effects of propionate on gene expression in human cerebromicrovascular endothelial cell line hCMEC/D3
Submitted on 8 March 2017, last updated on 2 March 2018, released on 5 March 2018
The experiment was designed to look at the effect (on gene expression) of exposing human cerebromicrovascular endothelial cell line hCMEC/D3 to propionate (3 micromolar) for 24 h, to determine if circulating metabolites have the potential to affect integrity of the blood-brain barrier.
transcription profiling by array, compound treatment design
Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier. Hoyles L, Snelling T, Umlai UK, Nicholson JK, Carding SR, Glen RC, McArthur S. 6(1):55 (2018), PMID:29562936