E-MTAB-4979 - RNA localization is a key determinant of neurite-enriched proteome - Riboseq
Last updated on 27 July 2016, released on 23 July 2017
RNA localization and local translation are important biological processes that underlie establishment of body axis, cell migration and synaptic plasticity. However, it is unclear to which extent mRNA localization contributes toward local proteome and how much of protein localization is achieved via protein transport or local translation of uniformly distributed mRNAs. To address this question, we performed genome-wide analysis of the local proteome, transcriptome, and translation rates in neurites and cell bodies of neurons differentiated from mouse embryonic stem cells.
translation profiling, cell component comparison design