E-MTAB-4510 - Transcription profiling by array of CMV-specific CD4+ T cells and CD4+CCR7-CD45RA- T cells (effector memory T cells) of CMV-seronegative individuals

Status
Submitted on 16 December 2014, last updated on 7 August 2016, released on 7 August 2016
Organism
Homo sapiens
Samples (9)
Array (1)
Protocols (6)
Description
Infection with cytomegalovirus is characterised by very strong and sustained T cell responses in peripheral blood. These expansions increase even further with age and research suggests CMV-specific T cells may contribute towards development of accelerated immune senescence and vascular disease in elderly people. In this study we compared the transcriptional profile of CD4+ T cells specific for two CMV-derived epitopes to that of CD4+CCR7-CD45RA- (effector memory) T cells of CMV-seronegative individuals. The aim was to get a better understanding of the nature of these virus-specific T cells and how they may contribute to immunopathology.
Experiment type
transcription profiling by array 
Contacts
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-4510.idf.txt
Sample and data relationshipE-MTAB-4510.sdrf.txt
Raw data (1)E-MTAB-4510.raw.1.zip
Array designA-MEXP-2320.adf.txt
Links