E-MTAB-4510 - Transcription profiling by array of CMV-specific CD4+ T cells and CD4+CCR7-CD45RA- T cells (effector memory T cells) of CMV-seronegative individuals
Submitted on 16 December 2014, last updated on 7 August 2016, released on 7 August 2016
Infection with cytomegalovirus is characterised by very strong and sustained T cell responses in peripheral blood. These expansions increase even further with age and research suggests CMV-specific T cells may contribute towards development of accelerated immune senescence and vascular disease in elderly people. In this study we compared the transcriptional profile of CD4+ T cells specific for two CMV-derived epitopes to that of CD4+CCR7-CD45RA- (effector memory) T cells of CMV-seronegative individuals. The aim was to get a better understanding of the nature of these virus-specific T cells and how they may contribute to immunopathology.
transcription profiling by array