E-MTAB-3610 - Transcriptional Profiling of 1,000 human cancer cell lines

Status
Submitted on 19 March 2014, released on 1 July 2015, last updated on 31 July 2015
Organism
Homo sapiens
Samples (1018)
Array (1)
Protocols (5)
Description
Basal expression profiles of 1,000 human cancer cell lines in the Genomics of Drug Sensitivity in Cancer (GDSC) panel [upcoming version], profiled using a diverse collection of 265 compounds. We have carried out an extensive computational exploration of the data to determine (1) to what extent does the mutational landscape of cancer cell lines recapitulate that seen in primary tumours, (2) what effect the status of these genomic features have on the variation in drug response; (3) whether genomic alterations acting in concert explain more of the variation in drug response; and (4) what is the predictive ability of these individual data-omics and at what extent this is improved when they are combined. [See publication]
Experiment type
transcription profiling by array 
Contact
Citation
A landscape of pharmacogenomic interactions in cancer. Iorio F*, Knijnenburg T*, Vis D*, Bignell GR*, Menden MP*, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Greninger P, van Dyk E, Chang H, Desilva H, Heyn H, Mironenko T, Moran Salama S, Richardson L, Saylos Puig S, Soleimani M, Tamborero D, Lopez-Bigas N, Ross-MacDonald P, Esteller M, Haber D, Stratton MR, Benes C, Wessels L‡, Saez-Rodriguez J‡, McDermott U‡, Garnett MJ‡ (*co-first, ‡co-senior).
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-3610.idf.txt
Sample and data relationshipE-MTAB-3610.sdrf.txt
Raw data (25)Click to browse raw data
Array designA-GEOD-13667.adf.txt
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