E-MTAB-3346 - Single-cell transcriptome sequencing from mouse mTECs
Submitted on 19 February 2015, released on 2 August 2015, last updated on 28 August 2015
Homo sapiens, Mus musculus
Promiscuous gene expression (pGE) of tissue-restricted antigens in medullary thyme ephitelial cells (mTECs) is essential for self-tolerance induction and to prevent autoimmunity. We sequenced single mTEC transcriptomes to explore gene expression heterogeneity and to discover patterns of regulation of pGE.
RNA-seq of coding RNA from single cells, population based design
Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells. Brennecke P, Reyes A, Pinto S, Rattay K, Nguyen M, Küchler R, Huber W, Kyewski B, Steinmetz LM. (2015), PMID:26237553