E-MTAB-2054 - Transcription profiling by array of maternal whole blood samples comparing gene expression in pregnancies where the fetus was hypoxic at birth compared to those where the fetus was normoxic at birth
Released on 8 May 2014, last updated on 12 June 2017
Microarray of whole blood maternal samples comparing the expression of genes in the maternal blood in pregnancies where the fetus was hypoxic at birth compared to those where the fetus was normoxic at birth. Intrapartum hypoxia is associated with severe neonatal morbidity and mortality. Current techniques to assess fetal hypoxic status during labour have a poor sensitivity. At birth, the lactate level in umbilical cord blood is used to assess the degree of fetal hypoxia during birth, such that a high lactate reflects a hypoxic fetus and a low lactate a normoxic fetus. We collected maternal blood prior to delivery and compared the expression of genes in the maternal blood in women delivering a normoxic or hypoxic fetus as evidenced by umbilcal cord blood levels.
transcription profiling by array, co-expression, in vivo, stimulus or stress
Quantifying circulating hypoxia-induced RNA transcripts in maternal blood to determine in utero fetal hypoxic status. Clare Whitehead, Wan T Teh, Susan P Walker, Cheryl Leung, Sonali Mendis, Luke Lamour and Stephen Tong.