E-MTAB-1785 - Transcription profiling by array of mouse organ of Corti from Ptprq-CAT-knockout homozygotes (functional null) and wildtype littermates
Released on 27 January 2014, last updated on 3 June 2014
Ptprq is one of the genes markedly downregulated in the diminuendo mouse, which carries a mutation in the microRNA miR-96. We carried out microarrays on mice homozygous for a functional null allele of Ptprq and their wildtype littermates to compare expression changes to those seen in diminuendo homozygotes and examine how much, if any, of the diminuendo transcriptional phenotype can be explained by the downregulation of Ptprq.
transcription profiling by array, co-expression, genetic modification, in vivo
A reduction in Ptprq associated with specific features of the deafness phenotype of the miR-96 mutant mouse diminuendo. Chen J, Johnson SL, Lewis MA, Hilton JM, Huma A, Marcotti W, Steel KP. The European Journal of Neuroscience (2014), PMID:24446963