E-MTAB-1724 - Transcription profiling by array of human peripheral blood mononuclear cells (PMBCs) treated with beta-interferon over a 18-hour time-course, as well as PBMCs from patients with/without type-1 diabetes or systemic lupus erythematosus
Released on 13 March 2014, last updated on 3 June 2014
Peripheral blood mononuclear cells were treated with beta-interferon for 2, 6 and 18 hours, and interferon-responsive genes identified. This 'signature' was then analysed in newly diagnosed and long-standing type-1 diabetics, as well as pre-diabetic children and individuals with systemic lupus erythematosus.
transcription profiling by array, in vitro, stimulus or stress, time series
A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes. Ferreira R.C., Guo H., Coulson R.M.R., Smyth D.J., Pekalski M.L., Burren O.S., Cutler A.J., Doecke J.D., Flint S., McKinney E.F., Lyons P.A., Smith K.G.C., Achenbach P., Beyerlein A., Dunger D.B., Wicker L.S., Todd J.A., Bonifacio E., Wallace C., Ziegler A-G. Diabetes (2014)
Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Dopico XC, Evangelou M, Ferreira RC, Guo H, Pekalski ML, Smyth DJ, Cooper N, Burren OS, Fulford AJ, Hennig BJ, Prentice AM, Ziegler AG, Bonifacio E, Wallace C, Todd JA. :7000 (2015), Europe PMC 25965853