E-MTAB-1323 - Transcription profiling by array of human matched skin samples from healthy adults before and after aesthetic scarification which creates burn wounds and scars
Last updated on 21 October 2013, released on 22 January 2014
Full thickness and deep partial thickness burn injuries heal by scarring. There are several mechanisms thought to be essential for the development of burn scars, but a challenge to studying the skin response to burn injury is that there are few animal models of burn scarring that are either clinically similar to human burn scars or are practical for most investigators to use. The purpose of this study was to examine the changes in RNA expression in human skin to burn injury. This was done by comparing pre-injury tissue from otherwise healthy adults undergoing aesthetic scarification created by branding with a hot metal object to serial samples of untreated wounds in the same subjects.
transcription profiling by array, all pairs, time series
RNA expression in untreated human burn wounds.