E-MEXP-862 - Transcription profiling of blood from human patients with chronic myeloid leukemia harboring different bcr-abl transcript variants
Submitted on 18 September 2006, released on 31 December 2008, last updated on 2 May 2014
Identification of differentially expressed genes in the blood of chronic phase patients with chronic myeloid leukemia (CML) harboring different bcr-abl transcript variants. All leukemic samples were collected prior to therapy at the time point of the initial diagnosis of CML.
transcription profiling by array, individual genetic characteristics
LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia. Frietsch JJ, Kastner C, Grunewald TG, Schweigel H, Nollau P, Ziermann J, Clement JH, La Rosée P, Hochhaus A, Butt E. Oncotarget 5(14):5257-5271 (2014)