E-MEXP-1682 - Transcription profiling of mouse naive T cells from T-cell specific furin knockouts and wild type littermates
Released on 27 June 2008, last updated on 2 May 2014
Purified naive (CD4+ CD62L+ CD44-) T cells from 10-11 weeks old T cell specific Furin knockout (CD4-cre fur flox/flox) and littermate wild type (fur flox/flox) control mice were profiled for gene expression using Affymetrix MOE 430 2.0 microarray platform.
transcription profiling by array, co-expression, ex vivo, genetic modification
Essential role of T cell-expressed proprotein convertase furin in maintaining peripheral tolerance.