E-HGMP-3 - Transcription profiling of intestinal tumour development in Min mice
Released on 25 October 2006, last updated on 12 October 2011
Tumours in Min mice arise as a result of aberrant b-catenin activity which then acts as a transcriptional activator and repressor of certain target genes. Some of these target genes will essential to the development of tumours. By comparing expression profiles of tumour tissue with normal intestinal mucosa, it is hoped that some of these genes will be identified. By including both small and large intestine tumours (ie two different tissue types) and by testing mice in different genetic backgrounds, it should be possible to identify genes which are generically changed during tumour development. Once identified, the genes need to be tested for their role -if any- in tumourigenesis through in-vitro experiments and genetic engineering of mice.
transcription profiling by array, disease state
Mohammad Ilyas <email@example.com>, unknown unknown
Expression profiling of murine intestinal adenomas reveals early deregulation of multiple matrix metalloproteinase (Mmp) genes. Cristina Martinez, Sumit Bhattacharya, Tom Freeman, Michael Churchman, Mohammad Ilyas.