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E-GEOD-9723 - Transcription profiling by array of human gingival epithelial cells infected with Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis

Released on 24 April 2009, last updated on 30 April 2015
Homo sapiens
Samples (12)
Array (1)
Protocols (7)
Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by co-culture with the oral pathogenic Porphyromonas gingivalis and Aggregatibacter (formerly actinobacillus) actinomycetemcomitans. We used microarrays to detail the global programme of gene expression underlying infection and identified distinct classes of up- and down-regulated genes during this process. Experiment Overall Design: Gingival epithelial HIGK cells were sham infected (CTRL) and infected with either the oral pathogenic P. gingivalis (Pg) or A. actinomycetemcomitans (Aa). These samples were hybridized to Affymetrix microarrays. Understanding how host cells have adapted to pathogens, and how barrier cells respond to limit their impact, provides a mechanistic biological basis of microbial disease in the mixed bacterial-human ecosystem of the oral cavity.
Experiment types
transcription profiling by array, disease state design
Distinct transcriptional profiles characterize oral epithelium-microbiota interactions. Martin Handfield, Jeffrey J Mans, Gaolin Zheng, M Cecilia Lopez, Song Mao, Ann Progulske-Fox, Giri Narasimhan, Henry V Baker, Richard J Lamont.
Investigation descriptionE-GEOD-9723.idf.txt
Sample and data relationshipE-GEOD-9723.sdrf.txt
Raw data (1)
Processed data (1)
Additional data (1)
Array designA-AFFY-33.adf.txt