Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-67884 - Furin deficiency efect on T cells
Released on 5 August 2015, last updated on 19 August 2015
Analysis of T-cells lacking the proprotein convertase furin. Proprotein convertases promote the proteolytic maturation of proproteins. Furin is induced in activated T-cells. Results provide insight into the function of furin in T-cells. CD4+CD62L+CD44- naive, CD4+CD62L-CD44+ memory and CD4+CD25+FoxP3+ regulatory T cells were isolated from Fur flox/flox and CD4 cre Fur flox/flox mice. Naive T cells were activated via TCR. Total RNA was extracted from all cells and hybridized to Affymetrix microarrays.
transcription profiling by array
Anna Oksanen, Anton Roebroek, Csaba Ortutay, Ethan M Shevach, Ivan Fuss, John Andersson, John Creemers, John J O´Shea, Lai Wei, Lili Xu, Marko Pesu, Martha Quezado, Nicolas Bouladoux, Saara Aittomäki, Warren Strober, Wendy T Watford, Yasmine Belkaid, Zsuzsanna Ortutay
Proprotein convertase FURIN regulates T cell receptor-induced transactivation. Ortutay Z, Oksanen A, Aittomï¿½ki S, Ortutay C, Pesu M.