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E-GEOD-66426 - New molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach [Affymetrix]

Status
Released on 18 February 2016, last updated on 27 February 2016
Organism
Homo sapiens
Samples (12)
Array (1)
Protocols (5)
Description
Platelet reactivity (PR) in cardiovascular (CV) patients is variable between individuals and modulates clinical outcome. However, the determinants of platelet reactivity are largely unknown. Integration of data derived from high-throughput omics technologies may yield novel insights into the molecular mechanisms that govern platelet reactivity. The aim of this study was to identify candidate genes modulating platelet reactivity in aspirin-treated cardiovascular patients PR was assessed in 110 CV patients treated with aspirin 100mg/d by aggregometry using several agonists. 12 CV patients with extreme high or low PR were selected for transcriptomics, proteomics and miRNA analysis. 2 extreme patient groups, 6 samples per group
Experiment type
transcription profiling by array 
Contacts
Mark Ibberson <geo@ncbi.nlm.nih.gov>, A Zufferey, D Schvartz, I Xenarios, J Reny, J Sanchez, M Docquier, M Ibberson, P Fontana, S Nolli
Citation
New molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach. Zufferey A, Ibberson M, Reny JL, Nolli S, Schvartz D, Docquier M, Xenarios I, Sanchez JC, Fontana P. , PMID:26883867
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-66426.idf.txt
Sample and data relationshipE-GEOD-66426.sdrf.txt
Raw data (1)E-GEOD-66426.raw.1.zip
Processed data (1)E-GEOD-66426.processed.1.zip
Array designA-AFFY-44.adf.txt
Links