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E-GEOD-62254 - Molecular analysis of gastric cancer identifies discrete subtypes associated with distinct clinical characteristics and survival outcomes: the ACRG (Asian Cancer Research Group) study [gastric tumors]

Status
Released on 17 April 2015, last updated on 27 April 2015
Organism
Homo sapiens
Samples (300)
Array (1)
Protocols (5)
Description
Gastric cancer, a leading cause of cancer related deaths, is a heterogeneous disease, with little consensus on molecular subclasses and their clinical relevance. We describe four molecular subtypes linked with distinct patterns of molecular alterations, disease progression and prognosis viz. a) Microsatellite Instable: hypermutated intestinal subtype tumors occurring in antrum, best overall prognosis, lower frequency of recurrence (22%), with liver metastasis in 23% of recurred cases b) Mesenchymal-like: diffuse tumors with worst prognosis, a tendency to occur at an earlier age and highest recurrence (63%) with peritoneal seeding in 64% of recurred cases, low frequency of molecular alterations c) TP53-inactive with TP53 loss, presence of focal amplifications and chromosomal instability d) TP53-active marked by EBV infection and PIK3CA mutations. The key molecular mechanisms and associated survival patterns are validated in multiple independent cohorts, to provide a consistent and unified framework for further preclinical and clinical research. ACRG Gastric cohort: microarray profiles from 300 gastric tumors from gastric cancer patients.
Experiment type
transcription profiling by array 
Contacts
Michael Nebozhyn <geo@ncbi.nlm.nih.gov>, Amit Aggarwal, Andrey Loboda, Chen Ronghua, Christoph Reinhard, Dai Hongyue, In-Gu Do, Jae M Bae, Jake Fu, James Hardwick, Jason C Ting, Jason G Jin, Jeeyun Lee, Jian Wang, Jiangang Liu, Joon H Lee, Kun Yu, Kyoung-Mee Kim, Lara Gong, Mark Ayers, Min G Choi, Patrick Tan, Razvan Cristescu, Se H Park, Seung T Kim, Shawn Liu, Sung Kim, Swee S Wong, Tae S Sohn, Won K Kang, Xiang S Ye, Yong G Yue
MIAME
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