Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-58700 - Drug screening and genomic analyses of HER2 positive breast cancer cell lines reveal predictors for treatment response [Expression profiling]
Released on 30 January 2015, last updated on 8 February 2015
Thirteen HER2 positive breast cancer cell lines were screened with 22 commercially available compounds, mainly targeting proteins in the ErbB2 signaling pathway, and the molecular mechanisms related to treatment response were sought. To search for response predictors, genomic and transcriptomic profiling, PIK3CA mutations and PTEN status were associated to the drug responses and several genes involved in the response of the compounds were identified. RNA from thirteen HER2 positive breast cancer cell lines was isolated and hybridized on Affymetrix arrays.
transcription profiling by array
Anne-Lise Børresen-Dale, Dagim S Tadele, Eldri U Due, Gunhild M Mælandsmo, Henrik Edgren, Kristine K Sahlberg, Merja Perälä, Olli Kallioniemi, Sandra Jernström, Suvi-Katri Leivonen, Vesa Hongisto