Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-57276 - Genomic analysis of low-grade serous ovarian carcinomas [ILOEF]
Released on 1 October 2014, last updated on 4 October 2014
Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread genomic change, and are commonly BRCA-pathway disrupted.We sought to identify differences in genomic copy number changes between co-existing borderline and invasive components of serous carcinoma. Paired co-existing borderline and invasive tumor components were sampled and profiled from formalin-fixed paraffin embedded tumors from 6 patients
comparative genomic hybridization by array
Dariush Etemadmoghadam <email@example.com>, Anna deFazio, Catherine Emmanuel, David Bowtell, Joshy George, Yoke-Eng Chiew