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E-GEOD-57276 - Genomic analysis of low-grade serous ovarian carcinomas [ILOEF]

Status
Released on 1 October 2014, last updated on 4 October 2014
Organism
Homo sapiens
Samples (10)
Array (1)
Protocols (7)
Description
Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread genomic change, and are commonly BRCA-pathway disrupted.We sought to identify differences in genomic copy number changes between co-existing borderline and invasive components of serous carcinoma. Paired co-existing borderline and invasive tumor components were sampled and profiled from formalin-fixed paraffin embedded tumors from 6 patients
Experiment type
comparative genomic hybridization by array 
Contacts
Dariush Etemadmoghadam <dariush.etemadmoghadam@petermac.org>, Anna deFazio, Catherine Emmanuel, David Bowtell, Joshy George, Yoke-Eng Chiew
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-57276.idf.txt
Sample and data relationshipE-GEOD-57276.sdrf.txt
Processed data (1)E-GEOD-57276.processed.1.zip
Additional data (1)E-GEOD-57276.additional.1.zip
Array designA-GEOD-18643.adf.txt
Links