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E-GEOD-54538 - Genome-wide expression profile on hiPSCs and hiPSC-derived CD33+ myeloid cells

Status
Released on 31 January 2014, last updated on 3 June 2014
Organism
Homo sapiens
Samples (21)
Array (1)
Protocols (7)
Description
To gain insights into which pathways might be dysregulated in JMML, we compared the transcriptome profiles among hiPSC and sorted CD33+ myeloid cells from control and patient samples. NS/JMML-derived CD33+ myeloid cells showed dysregulation in major biological processes. Moreover, a consistent expression pattern among sets of genes related to pluripotency and myeloid regulation was observed in the control, NS and NS/JMML CD33+ myeloid cells further supporting generally successful myelopoiesis. Total RNA obtained from hiPSC and sorted CD33+ myeloid cells (at day 14 of differentiation) from control and patient samples
Experiment type
transcription profiling by array 
Contacts
Angel Carlos Roman <aroman6@gmail.com>, Alessia Baccarini, Ana Sevilla, Angel C Roman, Aurélie Caye, Brian D Brown, Bruce D Gelb, Christoph Schaniel, Christopher Y Park, Dung-Fang Lee, Elisabetta Flex, Ge Yongchao, Hélène Cavé, Ihor R Lemischka, Ilan Riess, Jie Su, Kateri A Moore, Lisa Edelmann, Marco Tartaglia, Marion Strullu, Ninette Cohen, Patrick Raynal, Perundurai S Dhandapany, Safak Yalcin, Sawsan Bahieg, Sherly Pardo, Sonia Mulero-Navarro, Sunita D'Souza
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-54538.idf.txt
Sample and data relationshipE-GEOD-54538.sdrf.txt
Processed data (1)E-GEOD-54538.processed.1.zip
Additional data (1)E-GEOD-54538.additional.1.zip
Array designA-GEOD-10558.adf.txt
Links