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E-GEOD-51297 - Expression profiling of murine MYCN-driven neuroblastomas from LSL-MYCN; Dbh-iCre mice

Status
Released on 1 September 2014, last updated on 6 September 2014
Organism
Mus musculus
Samples (8)
Array (1)
Protocols (5)
Description
Amplification of MYCN is the most prominent genetic marker of high-stage neuroblastoma, a childhood tumor originating from the neural crest. We generated a transgenic mouse with Cre-conditional induction of MYCN in dopamine beta hydroxylase expressing cells that develops murine neuroblastomas. The expression profiles of six tumors from adrenals and two tumors from superial cervical gangliae were compared to three non-malignant adrenals from wildtype mice. These profiles of adrenals have been previously described (Molenaar et al., Nature Genetics 2012). Wild type samples are accessible at the AMC webpage: http://hgserver1.amc.nl/cgi-bin/r2/main.cgi, and accessible for registered users.
Experiment type
transcription profiling by array 
Contacts
Alexander Schramm <alexander.schramm@uk-essen.de>, Johannes Schulte, Kristina Althoff
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-51297.idf.txt
Sample and data relationshipE-GEOD-51297.sdrf.txt
Raw data (1)E-GEOD-51297.raw.1.zip
Processed data (1)E-GEOD-51297.processed.1.zip
Array designA-AFFY-45.adf.txt
Links