Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-50120 - Runx3 function in splenic NK cells activated in vivo by IL-15
Released on 22 January 2014, last updated on 8 July 2015
NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent. To identify Runx3 regulated genes, NK cells were isolated from spleen of IL15/Ra injected WT and Runx3-/- mice and sorted to obtain 3 subpopulations of immature (CD27) and mature (DP and CD11c) NK cells.
transcription profiling by array
Joseph Lotem <firstname.lastname@example.org>, Dena Leshkowitz, Ditsa Levanon, Yoram Groner
Runx3 Regulates Interleukin-15 Dependent Natural Killer Cell Activation. Levanon D, Negreanu V, Lotem J, Bone KR, Brenner O, Leshkowitz D, Groner Y. , PMID:24421391