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E-GEOD-50120 - Runx3 function in splenic NK cells activated in vivo by IL-15

Status
Released on 22 January 2014, last updated on 8 July 2015
Organism
Mus musculus
Samples (18)
Array (1)
Protocols (7)
Description
NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent. To identify Runx3 regulated genes, NK cells were isolated from spleen of IL15/Ra injected WT and Runx3-/- mice and sorted to obtain 3 subpopulations of immature (CD27) and mature (DP and CD11c) NK cells.
Experiment type
transcription profiling by array 
Contacts
Joseph Lotem <joseph.lotem@weizmann.ac.il>, Dena Leshkowitz, Ditsa Levanon, Yoram Groner
Citation
Runx3 Regulates Interleukin-15 Dependent Natural Killer Cell Activation. Levanon D, Negreanu V, Lotem J, Bone KR, Brenner O, Leshkowitz D, Groner Y. , PMID:24421391
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-50120.idf.txt
Sample and data relationshipE-GEOD-50120.sdrf.txt
Raw data (1)E-GEOD-50120.raw.1.zip
Processed data (1)E-GEOD-50120.processed.1.zip
Array designA-AFFY-130.adf.txt
Links