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E-GEOD-50041 - Comparative analysis of mouse oral cancer cell lines

Status
Released on 13 April 2014, last updated on 13 May 2014
Organism
Mus musculus
Samples (24)
Array (1)
Protocols (7)
Description
A comparative microarray analysis of indolent or aggressive mouse oral cancer cell lines was performed to identify gene expression signatures and specific molecules involved in aggressive tumor growth. We compared 3 indolent cell lines (MOC1, MOC22, MOC23) to 1 aggressive line and it's derivatives (MOC2, MOC2-7 and MOC2-10). We also included a cell line generated from a lymph node metastasis of the MOC2 tumor. The lines were all analyzed in triplicated except for MOC1 which was done in quadruplicate. Finally, we included duplicate samples of primary, normal C57BL/6 oral keratinocytes grown in the same media as the MOC cell lines.
Experiment type
transcription profiling by array 
Contacts
Citation
A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease. Onken MD, Winkler AE, Kanchi KL, Chalivendra V, Law JH, Rickert CG, Kallogjeri D, Judd NP, Dunn GP, Piccirillo JF, Lewis JS Jr, Mardis ER, Uppaluri R. , PMID:24668645
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-50041.idf.txt
Sample and data relationshipE-GEOD-50041.sdrf.txt
Processed data (1)E-GEOD-50041.processed.1.zip
Additional data (1)E-GEOD-50041.additional.1.zip
Array designA-MEXP-1174.adf.txt
Links