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E-GEOD-49119 - Histone demethylase RBP2 is critical for breast cancer progression and metastasis

Status
Released on 27 February 2014, last updated on 3 June 2014
Organism
Homo sapiens
Samples (9)
Array (1)
Protocols (5)
Description
To determine the roles of RBP2 in breast cancer metastasis, MDA-MD-231 cells were transfected with siRNAs against RBP2 or luciferase control, followed with gene expression microarray analysis and gene set enrichment analysis. These analyses revealed that RBP2 knockdown significantly decreased expression of genes linked to breast cancer metastasis to lung. Total RNA obtained from the breast cancer cell line MDA-MB231 72 hours after transfection with siRNA targeting KDM5A/RBP2/JARID1A, and targeting Luceferase gene as a control.
Experiment type
transcription profiling by array 
Contacts
Valentina Greco <valentina.greco@yale.edu>, Don Nguyen, Jian Cao, Qin Yan, Zongzhi Liu
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-49119.idf.txt
Sample and data relationshipE-GEOD-49119.sdrf.txt
Processed data (1)E-GEOD-49119.processed.1.zip
Additional data (1)E-GEOD-49119.additional.1.zip
Array designA-MEXP-1171.adf.txt
Links