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E-GEOD-46922 - Differences in gene expression and cytokines levels between newly diagnosed and chronic pediatric immune thrombocytopenia (ITP)

Status
Released on 5 August 2013, last updated on 3 June 2014
Organism
Homo sapiens
Samples (13)
Array (1)
Protocols (6)
Description
Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves but in some it becomes chronic. To investigate whether the two forms of the disease are similar or separate entities we performed DNA microarray analysis of T-cells from newly diagnosed children and children with chronic ITP. We found complete separation of the expression files between the two forms of the disease. Furthermore, the gene expression of several cytokines differed between the two forms of the disease. This was also reflected in plasma with increased levels of IL-16 and TWEAK and lower levels of IL-4 in newly diagnosed compared with chronic ITP. Thus, our data indicate that the two forms of the disease may be separate entities. Microarray expression analysis of mRNA in peripheral blood T-cell of Newly diagnosed ITP vs Chronic ITP
Experiment type
transcription profiling by array 
Contacts
Intawat Nookaew <intawat@chalmers.se>, Bob Olsson, Frida Strömberg, Hans Wadenvik, Karin Mellgren, Linlin Shao, Margareta Jernås, Ming Hou, Qian Wang, Xiuli Ju, Yu Hou
Citation
Differences in gene expression and cytokine levels between newly diagnosed and chronic pediatric ITP. Jern�s M, Hou Y, Str�mberg C�lind F, Shao L, Nookaew I, Wang Q, Ju X, Mellgren K, Wadenvik H, Hou M, Olsson B. , PMID:23869085
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-46922.idf.txt
Sample and data relationshipE-GEOD-46922.sdrf.txt
Raw data (1)E-GEOD-46922.raw.1.zip
Processed data (1)E-GEOD-46922.processed.1.zip
Array designA-AFFY-44.adf.txt
Links