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E-GEOD-46189 - The spatio-temporal program of DNA replication is driven by specific epigenetic signatures in human cells
Released on 1 May 2014, last updated on 31 May 2014
We report the application of single-molecule-based sequencing technology for high-throughput profiling of DNA replication origins in K562 mammalian cells. We have optimized a specific method of peak detection adapted to the signal produced by the sequencing of short nascent strands (SNS) that are specific of replication initiation, with the aim to have both a good sensitivity and specificity. We demonstrated the existence of the spatiao-temporal program of DNA replication driven by a specific epigenetic signature. K562 human cells; five samples subjected to SNS-Seq.
Jean-Charles Cadoret <email@example.com>, A Arneodo, B Audit, F Picard, J Poulain, J-C Cadoret, L Duret, M-N Prioleau