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E-GEOD-45734 - Changes in gene expression profiles of circulating B cells after influenza vaccination in healthy human subjects

Status
Released on 7 August 2013, last updated on 5 September 2013
Organism
Homo sapiens
Samples (55)
Protocols (3)
Description
Daily sampling of peripheral blood from human subjects vaccinated for influenza was done immediately before vaccination and for 10 days after vaccination. In B cells, 90% of transcriptomic variation in subjects who received influenza vaccine within the previous three years was explained by a single temporal pattern unique to the individual. A common set of 742 genes was strongly correlated with the migration of differentiating plasma cell subtypes. Five subjects, 11 time points per subject (pre-vaccination and daily for 10 days post-vaccination)
Experiment type
RNA-seq of coding RNA 
Contacts
Stephen Welle <stephen_welle@urmc.rochester.edu>, Alicia D Henn, Martin S Zand, Stephen L Welle
Citation
High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature. Henn AD, Wu S, Qiu X, Ruda M, Stover M, Yang H, Liu Z, Welle SL, Holden-Wiltse J, Wu H, Zand MS. , PMID:23900141
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-GEOD-45734.idf.txt
Sample and data relationshipE-GEOD-45734.sdrf.txt
Additional data (1)E-GEOD-45734.additional.1.zip
Links