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E-GEOD-45734 - Changes in gene expression profiles of circulating B cells after influenza vaccination in healthy human subjects
Released on 7 August 2013, last updated on 5 September 2013
Daily sampling of peripheral blood from human subjects vaccinated for influenza was done immediately before vaccination and for 10 days after vaccination. In B cells, 90% of transcriptomic variation in subjects who received influenza vaccine within the previous three years was explained by a single temporal pattern unique to the individual. A common set of 742 genes was strongly correlated with the migration of differentiating plasma cell subtypes. Five subjects, 11 time points per subject (pre-vaccination and daily for 10 days post-vaccination)
RNA-seq of coding RNA
Stephen Welle <firstname.lastname@example.org>, Alicia D Henn, Martin S Zand, Stephen L Welle
High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature. Henn AD, Wu S, Qiu X, Ruda M, Stover M, Yang H, Liu Z, Welle SL, Holden-Wiltse J, Wu H, Zand MS. , PMID:23900141