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E-GEOD-40878 - Expression of the placental transcriptome in fetal growth restriction in the Baboon is Dependent on Fetal Sex

Status
Released on 6 December 2013, last updated on 2 June 2014
Organism
Papio hamadryas
Samples (12)
Array (1)
Protocols (6)
Description
Fetal growth restriction (FGR) develops when fetal nutrient availability is compromised and increases the risk for perinatal complications and predisposes for offspring obesity, diabetes and cardiovascular disease later in life. Emerging evidence implicates changes in placental function in altered fetal growth and the subsequent development of adult disease. The susceptibility for disease in response to an adverse intrauterine environment differs distinctly between boys and girls, with girls typically having better outcomes. Here, we test the hypothesis that regulation of the placental transcriptome by moderate nutrient reduction is dependent on fetal sex. We used a non-human primate model of FGR in which maternal global food intake is reduced by 30% starting at gestational day (GD) 30. At GD 165 (term = GD 183) placental genome expression profiling was carried out followed by bioinformatics including pathway and network analysis. Surprisingly, there was no coordinated placental molecular response to decreased nutrient availability when analyzing the data without accounting for fetal sex. In contrast, female placentas exhibited a highly coordinated response that included up-regulation of genes in networks, pathways and functional groups related to programmed cell death and down-regulation of genes in networks, pathways and functional groups associated with cell proliferation. These changes were not apparent in the male placentas. Our data support the concept that female placentas initiate complex adaptive responses to an adverse intrauterine environment, which may contribute to increased survival and better pregnancy outcomes in girls. Total RNA obtained from 165dGA control female (n=3), control male (n=3), nutrient restricted female (n=3), and nutrient restricted male (n=3) pregnancies.
Experiment type
transcription profiling by array 
Contacts
Laura Cox <lcox@sfbrgenetics.org>, Jeremy P Glenn, Kennet Lange, Laura A Cox, Peter W Nathanielsz, Thomas Jansson
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-40878.idf.txt
Sample and data relationshipE-GEOD-40878.sdrf.txt
Processed data (1)E-GEOD-40878.processed.1.zip
Additional data (1)E-GEOD-40878.additional.1.zip
Array designA-MEXP-691.adf.txt
Links