Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.

E-GEOD-39387 - Discordant cellular response to pre-surgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification

Status
Released on 16 July 2012, last updated on 23 July 2012
Organism
Homo sapiens
Samples (2)
Array (1)
Protocols (8)
Description
This clinical case resulted from an ongoing trial at Vanderbilt University and abroad where ER+ breast cancer patients are administered 2-3 weeks of aromatase inhibitor therapy leading up to definitive surgical resection of the tumor. In this case, we describe a study patient presenting with bilateral primary ER+ breast tumors. Short term hormonal therapy substantially reduced proliferation in one tumor, while the second was essentially unchanged. Extensive molecular and genetic workup of the two tumors yielded divergent lesions in the two tumors; an activating KRAS mutation in the responsive tumor, and an amplification of the FGFR1 locus in the treatment-refractory tumor. Surgical tumor specimens from ER+ breast cancer patient 7603 who was administered letrozole for 16 days leading up to definitive surgery were utilized for RNA extraction and hybridization to Affymetrix Gene expression microarrays.
Experiment type
transcription profiling by array 
Contacts
Carlos L Arteaga, Justin M Balko
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-39387.idf.txt
Sample and data relationshipE-GEOD-39387.sdrf.txt
Raw data (1)E-GEOD-39387.raw.1.zip
Processed data (1)E-GEOD-39387.processed.1.zip
Array designA-GEOD-13158.adf.txt
R ExpressionSetE-GEOD-39387.eSet.r
Links