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E-GEOD-38900 - Genome-wide analysis of whole blood transcriptional response to Respiratory Syncytial Virus, Influenza and Rhinovirus lower respiratory tract infection (LRTI) in children

Status
Released on 12 November 2013, last updated on 2 June 2014
Organism
Homo sapiens
Samples (241)
Arrays (2)
Protocols (8)
Description
Analysis of transcriptional profiles in whole blood from children < 2 years of age (and healthy matched controls) with RSV, rhinovirus and influenza infection. The hypothesis tested is that transcriptional profile heterogeneity will reflect patient clinical heterogeneity and that RSV infection induces a distinct host response compared with influenza and rhinovirus infection Total RNA extracted from whole blood (lysed in Tempus tubes) drawn from individual pediatric patients with acute RSV, influenza and Rhinovirus lower respiratory tract infection. A total of 241 samples are analyzed: 135 with acute RSV LRTI, 30 with Rhinovirus LRTI, 16 with influenza LRTI, 39 age-sex matched healthy controls and 21 samples obtained one month after the acute hospitalization in children with RSV. Samples GSM1226237-GSM1226272, which were hybridized to Platform GPL10558, were normalized separately from the other Samples in this Series, which were hybridized to Platform GPL6884. 'GSE38900_non-normalized_GSM1226237-GSM1226272.txt.gz' includes the non-normalized data for Samples GSM1226237-GSM1226272; 'GSE38900_non-normalized.txt.gz' includes the non-normalized data for the other Samples.
Experiment type
transcription profiling by array 
Contacts
Nicole Baldwin <geo@ncbi.nlm.nih.gov>, Alejandro Jordan-Villegas, Asuncion Meijas, Blerta Dimo, Carla Garcia, Damien Chaussabel, Derek Blankenship, Jacques Banchereau, M. C Suarez-Arrabal, Monica I Ardura, Nicholas M Suarez, Octavio Ramilo, Tuomas Jartti, Zhaohui Xu
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-38900.idf.txt
Sample and data relationshipE-GEOD-38900.sdrf.txt
Processed data (1)E-GEOD-38900.processed.1.zip
Additional data (1)E-GEOD-38900.additional.1.zip
Array designsA-GEOD-10558.adf.txt, A-MEXP-1173.adf.txt
Links