Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-35993 - Notch regulated miRNAs in human T-ALL cell line
Released on 22 May 2012, last updated on 3 May 2014
In an attempt to identify miRNAs regulated by oncogenic Notch signaling, we performed miRNA profiling of human T-cell acute lymphoblastic leukemia (T-ALL) cells with or without the treatment of γ-secretase inhibitor (GSI) to block Notch signaling. We found miR-223 levels to increase after GSI treatment suggesting that active Notch signaling represses miR-223 expression. We confirmed insulin-like growth factor-1 receptor (IGF1R) to be regulated by miR-223, but were unable to demonstrate functional effects on T-ALL cell growth by overexpression or knock-down of miR-223 alone. 4 samples analyzed, 2 cell lines each treated (GSI) and mock treated
transcription profiling by array
Andrew P Weng, Sam D Gusscott
Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL. Gusscott S, Kuchenbauer F, Humphries RK, Weng AP. , PMID:22424712