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E-GEOD-35993 - Notch regulated miRNAs in human T-ALL cell line

Status
Released on 22 May 2012, last updated on 3 May 2014
Organism
Homo sapiens
Samples (8)
Array (1)
Protocols (8)
Description
In an attempt to identify miRNAs regulated by oncogenic Notch signaling, we performed miRNA profiling of human T-cell acute lymphoblastic leukemia (T-ALL) cells with or without the treatment of γ-secretase inhibitor (GSI) to block Notch signaling. We found miR-223 levels to increase after GSI treatment suggesting that active Notch signaling represses miR-223 expression. We confirmed insulin-like growth factor-1 receptor (IGF1R) to be regulated by miR-223, but were unable to demonstrate functional effects on T-ALL cell growth by overexpression or knock-down of miR-223 alone. 4 samples analyzed, 2 cell lines each treated (GSI) and mock treated
Experiment type
transcription profiling by array 
Contacts
Andrew P Weng, Sam D Gusscott
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-35993.idf.txt
Sample and data relationshipE-GEOD-35993.sdrf.txt
Raw data (1)E-GEOD-35993.raw.1.zip
Processed data (1)E-GEOD-35993.processed.1.zip
Array designA-MEXP-1519.adf.txt
Links