Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-35400 - HGAL Enhances BCR-mediated Syk Activation, Leading to Lymphoid Hyperplasia and Amyloidosis
Released on 22 May 2013, last updated on 17 June 2013
Gene expression data from CD22+B220+ FACS-purified splenocytes of adult Sca1-HGAL knock-in CBAxC57BL/6J mice or wild-type littermates. Transgenic mice expressing HGAL (GCET2) under control of the Sca1 (Ly-6E.1) promoter were generated. CD22 and B220 dual-positive B-cells were FACS purified from spleens of adult transgenic mice and wildtype littermates, total-RNA was isolated, and transcriptional profiling performed using GeneChip® Mouse Gene 1.0 ST Arrays.
transcription profiling by array
Michael R Green <email@example.com>, Ash A Alizadeh, Isidro Sánchez-García, Izidore S Lossos
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation. Romero-Camarero I, Jiang X, Natkunam Y, Lu X, Vicente-Dueï¿½as C, Gonzalez-Herrero I, Flores T, Garcia JL, McNamara G, Kunder C, Zhao S, Segura V, Fontan L, Martï¿½nez-Climent JA, Garcï¿½a-Criado FJ, Theis JD, Dogan A, Campos-Sï¿½nchez E, Green MR, Alizadeh AA, Cobaleda C, Sï¿½nchez-Garcï¿½a I, Lossos IS. , PMID:23299888