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E-GEOD-35400 - HGAL Enhances BCR-mediated Syk Activation, Leading to Lymphoid Hyperplasia and Amyloidosis

Released on 22 May 2013, last updated on 17 June 2013
Mus musculus
Samples (8)
Array (1)
Protocols (5)
Gene expression data from CD22+B220+ FACS-purified splenocytes of adult Sca1-HGAL knock-in CBAxC57BL/6J mice or wild-type littermates. Transgenic mice expressing HGAL (GCET2) under control of the Sca1 (Ly-6E.1) promoter were generated. CD22 and B220 dual-positive B-cells were FACS purified from spleens of adult transgenic mice and wildtype littermates, total-RNA was isolated, and transcriptional profiling performed using GeneChip® Mouse Gene 1.0 ST Arrays.
Experiment type
transcription profiling by array 
Michael R Green <>, Ash A Alizadeh, Isidro Sánchez-García, Izidore S Lossos
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation. Romero-Camarero I, Jiang X, Natkunam Y, Lu X, Vicente-Due�as C, Gonzalez-Herrero I, Flores T, Garcia JL, McNamara G, Kunder C, Zhao S, Segura V, Fontan L, Mart�nez-Climent JA, Garc�a-Criado FJ, Theis JD, Dogan A, Campos-S�nchez E, Green MR, Alizadeh AA, Cobaleda C, S�nchez-Garc�a I, Lossos IS. , PMID:23299888
Investigation descriptionE-GEOD-35400.idf.txt
Sample and data relationshipE-GEOD-35400.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-AFFY-130.adf.txt