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E-GEOD-31767 - FOXM1 Orchestrates a Global Methylation Signature that Mimics the Cancer Epigenome

Status
Released on 18 April 2012, last updated on 3 May 2014
Organism
Homo sapiens
Samples (6)
Array (1)
Protocols (9)
Description
Aberrant upregulation of a single oncogene FOXM1 in primary normal human oral epithelial cells orchestrated a cancer-like methylome landscape This study have identified a unique FOXM1-induced epigenetic signature which may have potentials as biomarkers for early oral cancer screening, diagnostic and/or therapeutic interventions Comparisons of primary human normal oral keratinocytes transduced with either EGFP (control) or FOXM1B and a head and neck squamous cell carcinoma cell line SCC15
Experiment type
methylation profiling by array 
Contacts
Citation
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. Teh MT, Gemenetzidis E, Patel D, Tariq R, Nadir A, Bahta AW, Waseem A, Hutchison IL. , PMID:22461910
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-31767.idf.txt
Sample and data relationshipE-GEOD-31767.sdrf.txt
Raw data (2)E-GEOD-31767.raw.1.zip, E-GEOD-31767.raw.2.zip
Processed data (1)E-GEOD-31767.processed.1.zip
Array designA-GEOD-14361.adf.txt
Links