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E-GEOD-31048 - Expression data from normal B cells and chronic lymphocytic leukemia B cells -- with/without treatment of Wnt3a

Released on 29 August 2013, last updated on 2 June 2014
Homo sapiens
Samples (221)
Array (1)
Protocols (6)
Wnt pathway is dysregulated in CLL-We characterized Wnt pathway gene expression in normal B and CLL-B cells and identified Wnt targets in normal B and CLL-B cells through this data set. In this dataset, we included normal B cells and CLL-B cells for Wnt pathway gene expression. This leads to the identification of 62 Wnt pathway components which are differnetially expressed between normal and CLl-B cells. We also included normal B cells and CLL-B cells with or without Wnt3a treatment and identified 468 and 676 Wnt regulated genes in normal and CLL B cells, respectively. 24 normal B cells and 179 CLL-B cells were used in the Wnt pathway gene expression analysis. Three normal and three CLL samples were included in the identification of Wnt regulated targets
Experiment type
transcription profiling by array 
Aviv Regev, Bethany Tesar, Catherine J Wu, Donna Neuberg, Jennifer R Brown, Kristen E Stevenson, Lili Wang, Nathalie Pochet, Wandi Zhang