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E-GEOD-2739 - Transcription profiling by array of rat brains after treatment with candesartan

Status
Released on 3 November 2007, last updated on 2 March 2012
Organism
Rattus norvegicus
Samples (9)
Array (1)
Protocols (4)
Description
In hypertension, abnormal regulation of microcirculation and endothelial dysfunction enhances vulnerability to hypertensive brain damage. In addition to lowering blood pressure, blockade of Angiotensin II AT1 receptors protects against stroke and stress in different animal models and this treatment may be of therapeutic advantage. We studied gene expression using Affymetrix Rat Genome U34A arrays from brain microvessels of spontaneously hypertensive rats (SHR) and their normotensive Wistar Kyoto controls (WKY) rats treated with an AT1 antagonist (candesartan, 0.3 mg/kg/day) or vehicle via osmotic minipumps for 4 weeks. Experiment Overall Design: brain microvessels from hypertensive and normotensive rats treated with candesartan and vehicle were analyzed
Experiment types
transcription profiling by array, co-expression, compound treatment, disease state
Contact
Citation
AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats. Jin Zhou, Jaroslav Pavel, Miroslava Macova, Zu-Xi Yu, Hans Imboden, Linna Ge, Tsuyoshi Nishioku, Jingtao Dou, Elizabeth Delgiacco, Juan M Saavedra. , PMID:16601219
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-2739.idf.txt
Sample and data relationshipE-GEOD-2739.sdrf.txt
Raw data (1)E-GEOD-2739.raw.1.zip
Processed data (1)E-GEOD-2739.processed.1.zip
Array designA-AFFY-18.adf.txt
R ExpressionSetE-GEOD-2739.eSet.r
Links