Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-2739 - Transcription profiling by array of rat brains after treatment with candesartan
Released on 3 November 2007, last updated on 2 March 2012
In hypertension, abnormal regulation of microcirculation and endothelial dysfunction enhances vulnerability to hypertensive brain damage. In addition to lowering blood pressure, blockade of Angiotensin II AT1 receptors protects against stroke and stress in different animal models and this treatment may be of therapeutic advantage. We studied gene expression using Affymetrix Rat Genome U34A arrays from brain microvessels of spontaneously hypertensive rats (SHR) and their normotensive Wistar Kyoto controls (WKY) rats treated with an AT1 antagonist (candesartan, 0.3 mg/kg/day) or vehicle via osmotic minipumps for 4 weeks. Experiment Overall Design: brain microvessels from hypertensive and normotensive rats treated with candesartan and vehicle were analyzed
transcription profiling by array, co-expression, compound treatment, disease state
AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats. Jin Zhou, Jaroslav Pavel, Miroslava Macova, Zu-Xi Yu, Hans Imboden, Linna Ge, Tsuyoshi Nishioku, Jingtao Dou, Elizabeth Delgiacco, Juan M Saavedra. , PMID:16601219