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E-GEOD-24427 - Expression data of multiple sclerosis patients receiving Interferon-beta therapy

Released on 29 September 2010, last updated on 27 March 2012
Homo sapiens
Samples (250)
Arrays (2)
Protocols (9)
The purpose of this study was to characterize the transcriptional effects induced by subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 25 MS patients within the first two years of IFN-beta administration. EDTA blood samples were drawn from all patients immediately before first, second, month 1, 12, and 24 IFN-beta injection. Total RNA of Ficoll-isolated peripheral blood mononuclear cells from each sample was extracted, labelled and hybridized to Affymetrix Human Genome U133 A and B arrays to quantify the mRNA levels.
Experiment type
transcription profiling by array 
Robert Goertsches <>, Dirk Koczan, Michael Hecker, Robert H Goertsches, Uwe K Zettl