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E-GEOD-22886 - Expression profiles from a variety of resting and activated human immune cells

Status
Released on 13 July 2010, last updated on 27 March 2012
Organism
Homo sapiens
Samples (228)
Arrays (2)
Protocols (9)
Description
Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. In order to identify such patterns, we set out to broadly profile gene expression in a variety of immune cells. We isolated twelve different types of human leukocytes from peripheral blood and bone marrow, treated them to induce activation and/or differentiation, and profiled their gene expression before and after treatment. The twelve cell types are: B cells, CD14+ cells, CD4+ CD45RO+ CD45RA- T cells, CD4+ T cells, CD8+ T cells, IgG/IgA memory B cells, IgM memory B cells, Monocytes, NK cells, Neutrophils, Plasma cells from bone marrow, and Plasma cells from PBMC.
Experiment type
transcription profiling by array 
Contacts
Alex Abbas <abbas@gene.com>, Alexander R Abbas, Andrew C Chan, Austin Gurney, Daryl Baldwin, Flavius Martin, Hilary F Clark, Menno van Lookeren Campagne, P M Williams, Paul Godowski, Sherman Fong, Wenjun Ouyang, Yan Ma
Citation
Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data. Abbas AR, Baldwin D, Ma Y, Ouyang W, Gurney A, Martin F, Fong S, van Lookeren Campagne M, Godowski P, Williams PM, Chan AC, Clark HF. , PMID:15789058
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